Administered orally, intramuscularly and intravenously. The dose, method and scheme of use, the duration of therapy are determined individually, depending on the indications, clinical situation, patient's age and dosage form.

Hypersensitivity to clemastine or other antihistamines of similar chemical structure; pregnancy, breastfeeding period; taking MAO inhibitors, lower respiratory tract diseases (including bronchial asthma), childhood - depending on the dosage form.

With caution: in patients with stenosing gastric ulcer, pyloroduodenal obstruction, bladder neck obstruction, as well as prostatic hypertrophy, accompanied by urinary retention, with increased intraocular pressure, hyperthyroidism, diseases of the cardiovascular system, including arterial hypertension.

Application during pregnancy and lactation:

Contraindicated for use during pregnancy and lactation (breastfeeding).

Application in children:

It can be used in children according to indications, in doses and dosage forms recommended according to age. It is necessary to strictly follow the instructions in the instructions for clemastine preparations for contraindications to the use of specific dosage forms of clemastine in children of different ages.

From the nervous system: often - increased fatigue, drowsiness, sedation, weakness, fatigue, lethargy, impaired coordination of movements; infrequently - dizziness; rarely - headache, tremor, stimulating effect.

From the digestive system: rarely - dyspepsia, nausea, vomiting, gastralgia; very rarely - constipation, dry mouth; in some cases - decreased appetite, diarrhea.

From the senses: rarely - impaired clarity of visual perception, diplopia, acute labyrinthitis, tinnitus.

From the urinary system: very rarely - frequent or difficult urination.

On the part of the respiratory system: rarely - thickening of bronchial secretions and difficulty in sputum discharge, a feeling of pressure in the chest, respiratory failure, nasal congestion.

On the part of the cardiovascular system: rarely - lowering blood pressure (more often in elderly patients), extrasystole; very rarely - palpitations.

From the hematopoietic system: rarely - hemolytic anemia, thrombocytopenia, agranulocytosis.

On the part of the skin and subcutaneous tissues: rarely - skin rash.

From the immune system: rarely - photosensitivity, anaphylactic shock.

With the simultaneous use of clemastine, it potentiates the effect of drugs that depress the central nervous system (hypnotics, sedatives, tranquilizers), as well as ethanol and ethanol-containing drugs.

Incompatible with the simultaneous administration of MAO inhibitors.

Symptoms: An overdose of antihistamines can lead to both a depressing and a stimulating effect on the central nervous system. CNS stimulation is more common in children. Manifestations of anticholinergic action may also develop: dry mouth, fixed pupil dilation, rush of blood to the upper half of the body, gastrointestinal disorders (nausea, epigastric pain, vomiting).

Treatment: if the patient does not vomit spontaneously, then it should be induced artificially (only if the patient's consciousness is preserved). If 3 hours or a little more have passed since taking the drug, you can wash the stomach using isotonic sodium chloride solution. You can also give a saline laxative. Symptomatic therapy is also indicated.