Indications for use of Panangin Forte are:

To eliminate the deficiency of potassium and magnesium as part of combination therapy for various manifestations of coronary heart disease (including acute myocardial infarction); chronic heart failure; cardiac arrhythmias (including arrhythmias caused by an overdose of cardiac glycosides).

Composition for one tablet:

Pill core

Active ingredients: potassium asparaginate (in the form of potassium asparaginate

hemihydrate), magnesium asparaginate (in the form of magnesium aspartate

tetrahydrate);

Excipients: corn starch, talc, magnesium

stearate, potato starch, povidone, silicon dioxide

colloidal;

Tablet shell: talc, butyl methacrylate copolymer, titanium dioxide

(color index: C.I. 77891, E171) 5.30 mg, macrogol-6000 1.40 mg.

Description:

Oval, biconvex film-coated tablets, white or nearly

white, with a slightly glossy surface, engraved with "A83" on one side,

almost odorless. The cross section is white or almost white.

Pharmacotherapeutic group: potassium and magnesium drug.

ATX code: А12СХ

Pharmacological properties:

Pharmacodynamics:

The most important intracellular cations of potassium (K) and magnesium (Mg ++) play a key role in the functioning of numerous enzymes, in the formation of bonds between macromolecules and intracellular structures, and in the mechanism of muscle contractility. Intra- and extracellular ratio of potassium, calcium, sodium and

magnesium has an effect on myocardial contractility. Endogenous asparaginate acts as a conductor of ions: it has a high affinity for cells, due to the slight dissociation of its salts, ions in the form of complex compounds penetrate into the cell. Magnesium asparaginate and potassium asparaginate improve myocardial metabolism.

Lack of magnesium / potassium predisposes to the development of arterial hypertension, atherosclerosis of the coronary arteries, arrhythmias and metabolic changes in the myocardium.

Each tablet of Panangin® Forte contains 280 mg of magnesium asparaginate and 316 mg of potassium asparaginate, which is 2 times higher than the content of active ingredients in Panangin®, film-coated tablets. The daily dose of Panangin® Forte: 1 tablet 3 times a day, corresponds to the daily dose of Panangin®: 2 tablets 3 times a day. Taking a single dose of Panangin® Forte in the form of one tablet makes the treatment more convenient for the patient.

Pharmacokinetics:

Potassium and magnesium aspartates are intensively absorbed in the intestine, mainly in the small intestine. Excreted by the kidneys.