Inside, parenterally. The daily dose is 30-160 mg / kg, the frequency of administration is 2-4 times a day. Inside it is prescribed during meals or on an empty stomach; tablets and capsules should be taken with a liquid (water, juice). Parenterally prescribed in case of impossibility of oral administration, in the same daily dose.

In the symptomatic treatment of chronic psychoorganic syndrome, depending on the severity of symptoms, 1.2-2.4 g are prescribed, and during the first week - 4.8 g per day.

When treating the consequences of a stroke (chronic stage), 4.8 g / day is prescribed. In the treatment of coma, as well as perception difficulties in persons with brain injuries, the initial dose is 9-12 g / day, the maintenance dose is 2.4 g / day. Treatment lasts at least 3 weeks.

With alcohol withdrawal syndrome - 12 g / day. The maintenance dose is 2.4 g / day. Treatment of dizziness and related balance disorders - 2.4-4.8 g per day.

For children, for the correction of learning disabilities, the dose is 3.3 g / day (approximately 8 ml of a 20% solution for oral administration twice a day). Treatment continues throughout the school year.

With cortical myoclonus, treatment begins at 7.2 g / day, every 3-4 days the dose is increased by 4.8 g / day until a maximum dose of 24 g / day is reached. Treatment continues throughout the entire period of the disease. Every 6 months, attempts are made to reduce the dose or discontinue the drug, to prevent an attack, gradually reducing the dose by 1.2 g every 2 days. In the absence of effect or insignificant therapeutic effect, treatment is stopped.

In sickle cell disease, the daily prophylactic dose is 160 mg / kg, divided into four equal doses. During the crisis - 300 mg / kg IV. This dosage can be prescribed for children from 1 year old.

Dosing for patients with impaired renal function

Since Nootropil is excreted from the body by the kidneys, care should be taken when treating patients with renal insufficiency and the drug should be prescribed in accordance with the following dosing regimen:

At Cl creatinine> 80 ml / min (normal) - the usual dose; with mild renal failure (Cl creatinine 50-79 ml / min) - 2/3 of the usual dose in 2-3 doses; with an average degree of renal failure (Cl creatinine 30-49 ml / min) - 1/3 of the usual dose in 2 divided doses; for severe (Cl creatinine <30 ml / min) - 1/6 of the usual dose, once; at the final stage, the drug is contraindicated.

For elderly patients, the dose is corrected in the presence of renal failure and with prolonged therapy, it is necessary to control the functional state of the kidneys.

Dosing for patients with impaired liver function. Patients with impaired liver function do not need dose adjustment. For patients with impaired renal and liver function, dosing is carried out according to the above scheme (see Dosing for patients with impaired renal function).

Hypersensitivity, including to pyrrolidone derivatives; hemorrhagic stroke, severe renal dysfunction, pregnancy, breastfeeding, infancy up to 1 year.

Dizziness, tremors, nervousness, agitation, incl. sexual, irritability, anxiety, sleep disturbance, weakness, drowsiness, nausea, vomiting, diarrhea, abdominal pain, increased frequency of attacks of coronary insufficiency.

Increases the effectiveness of antidepressants. In old and old age, it enhances the effect of antianginal drugs, reduces the need for nitroglycerin.

Symptoms: more pronounced side effect symptoms. Treatment: symptomatic.