Before taking the drug, the patient should consult a doctor.

Adults are recommended to take 6-8 tablets / day.

Children over 6 years old (body weight over 20 kg) - 4-6 tablets / day.

The daily dose should be divided into 2-3 doses, taken with meals.

The tablets should be taken with a glass of water.

Treatment should be discontinued immediately after the normalization of the concentration of magnesium in the blood.

Application during pregnancy and lactation:

Pregnancy:

Clinical experience of using the drug in a sufficient number of pregnant women did not reveal any adverse effect on the occurrence of fetal malformations or fetotoxic effects.

Magne B6® can be used during pregnancy only if necessary and on the recommendation of a doctor.

Breastfeeding period:

Magnesium passes into breast milk. Avoid using the drug during breastfeeding.

Application for impaired renal function:

The drug is prescribed with caution in case of moderate renal insufficiency. there is a risk of developing hypermagnesemia.

The drug is contraindicated in severe renal failure (CC less than 30 ml / min).

Application in children:

Contraindication: children under 6 years of age.

• Hypersensitivity to drug components;
• severe renal failure (CC <30 ml / min);
• children under 6 years old;
• fructose intolerance, glucose-galactose malabsorption syndrome, sucrase-isomaltase deficiency;
• simultaneous administration of levodopa.

With caution: with a moderate degree of renal failure, because there is a risk of developing hypermagnesemia.

According to the WHO, adverse effects are classified according to their frequency of development as follows: very often (≥1 / 10), often (≥1 / 100, <1/10), infrequently (≥1 / 1000, <1/100), rarely (? 1/10 000, <1/1000), very rarely (<1/10 000), frequency unknown (frequency of occurrence of events cannot be determined from the available data).

From the immune system: very rarely - allergic reactions, including skin reactions (urticaria, itching).

From the digestive system: the frequency is unknown - diarrhea, abdominal pain.

Contraindicated combinations

With levodopa: the activity of levodopa is inhibited by pyridoxine (if the intake of this drug is not combined with the intake of peripheral decarboxylase inhibitors of aromatic L-amino acids). Any amount of pyridoxine should be avoided unless levodopa is taken in combination with aromatic L-amino acid peripheral decarboxylase inhibitors.

Combinations not recommended

The simultaneous use of drugs containing phosphates or calcium salts can impair the absorption of magnesium in the intestine.

Combinations to be taken into account

When prescribing antibiotics of the tetracycline group inside, an interval of at least 3 hours must be observed between the ingestion of tetracycline and Magne B6®, because magnesium preparations reduce the absorption of tetracyclines.

With normal kidney function, an overdose of magnesium when taken orally usually does not lead to toxic reactions. However, in the case of renal failure, magnesium poisoning may develop. The severity of symptoms depends on the concentration of magnesium in the blood.

Symptoms: decreased blood pressure, nausea, vomiting, central nervous system depression, decreased reflexes, ECG changes, respiratory depression, coma, cardiac arrest and respiratory paralysis, anuric syndrome.

Treatment: rehydration, forced diuresis. Renal failure requires hemodialysis or peritoneal dialysis.