Ibuprofen is prescribed for adults and children over 12 years old by mouth, in tablets of 200 mg 3-4 times a day. To achieve a quick therapeutic effect, the dose can be increased to 400 mg (2 tablets) 3 times a day. When the therapeutic effect is achieved, the daily dose of the drug is reduced to 600-800 mg. The morning dose is taken before meals with plenty of water (for faster absorption of the drug). The remaining doses are taken throughout the day after meals. The maximum daily dose is 1200 mg (do not exceed 6 tablets in 24 hours). A repeated dose should be taken no more often than after 4 hours. The duration of the drug use without consulting a doctor is not more than 5 days. Do not use in children under 12 years of age without consulting a doctor.

Hypersensitivity to any of the ingredients that make up the drug. A history of hypersensitivity to acetylsalicylic acid or other NSAIDs, including a history of an attack of bronchial obstruction, rhinitis, urticaria after taking acetylsalicylic acid or other NSAIDs. Erosive and ulcerative diseases of the gastrointestinal tract in the acute stage (including peptic ulcer of the stomach and duodenum, Crohn's disease, ulcerative colitis). Hemophilia and other blood clotting disorders (including hypocoagulation), hemorrhagic diathesis. The period after coronary artery bypass grafting. Gastrointestinal bleeding and intracranial hemorrhage. Severe liver failure or active liver disease. Severe renal failure, confirmed hyperkalemia. Pregnancy (III trimester). Children under 6 years old.

Precautions:

Elderly age, heart failure, arterial hypertension, ischemic heart disease, cerebrovascular diseases, dyslipidemia, diabetes mellitus, peripheral arterial disease, smoking, frequent alcohol consumption, liver cirrhosis with portal hypertension, hepatic and / or renal failure, nephrotic syndrome, hyperbilirubinemia, peptic ulcer disease of the stomach and duodenum (in history), gastritis, enteritis, colitis, blood diseases of unknown etiology (leukopenia and anemia), pregnancy (I-II) trimester, lactation period, children's age from 6 to 12 years .. Children from 6 to 12 years: 1 tablet no more than 4 times a day, the drug can be used only if the child's body weight is more than 20 kg. The interval between taking the tablets is at least 6 hours (daily dose is not more than 30 mg / kg).

Hypersensitivity to any of the ingredients that make up the drug. A history of hypersensitivity to acetylsalicylic acid or other NSAIDs, including a history of an attack of bronchial obstruction, rhinitis, urticaria after taking acetylsalicylic acid or other NSAIDs. Erosive and ulcerative diseases of the gastrointestinal tract in the acute stage (including peptic ulcer of the stomach and duodenum, Crohn's disease, ulcerative colitis). Hemophilia and other blood clotting disorders (including hypocoagulation), hemorrhagic diathesis. The period after coronary artery bypass grafting. Gastrointestinal bleeding and intracranial hemorrhage. Severe liver failure or active liver disease. Severe renal failure, confirmed hyperkalemia. Pregnancy (III trimester). Children under 6 years old.

With the simultaneous use of ibuprofen reduces the effect of antihypertensive drugs (ACE inhibitors, beta-blockers), diuretics (furosemide, hydrochlorothiazide).

With simultaneous use with anticoagulants, their effect may be enhanced.

With simultaneous use with GCS, the risk of developing side effects from the gastrointestinal tract increases.

With simultaneous use, ibuprofen can displace indirect anticoagulants (acenocoumarol), hydantoin derivatives (phenytoin), oral hypoglycemic drugs, sulfonylurea derivatives from compounds with blood plasma proteins.

With simultaneous use with amlodipine, a slight decrease in the antihypertensive effect of amlodipine is possible; with acetylsalicylic acid - the concentration of ibuprofen in the blood plasma decreases; with baclofen - a case of intensification of the toxic effect of baclofen is described.

With simultaneous use with warfarin, an increase in bleeding time is possible, microhematuria, hematomas were also observed; with captopril - it is possible to reduce the antihypertensive effect of captopril; with cholestyramine - a moderate decrease in ibuprofen absorption.

With simultaneous use with lithium carbonate, the concentration of lithium in the blood plasma increases.

With simultaneous use with magnesium hydroxide, the initial absorption of ibuprofen increases; with methotrexate - the toxicity of methotrexate increases.

The simultaneous use of NSAIDs and cardiac glycosides can lead to worsening heart failure, a decrease in the glomerular filtration rate and an increase in the concentration of cardiac glycosides in the blood plasma.

There is evidence of the likelihood of an increase in the concentration of methotrexate in the blood plasma during the use of NSAIDs.

With the simultaneous use of NSAIDs and cyclosporine, the risk of nephrotoxicity increases.

NSAIDs can reduce the effectiveness of mifepristone, so NSAIDs should be started no earlier than 8-12 days after the end of mifepristone.

With the simultaneous use of NSAIDs and tacrolimus, the risk of nephrotoxicity may increase.

The simultaneous use of NSAIDs and zidovudine can lead to an increase in hematotoxicity. There is evidence of an increased risk of hemarthrosis and hematomas in HIV-positive patients with hemophilia who received co-treatment with zidovudine and ibuprofen.

In patients receiving concomitant treatment with NSAIDs and quinolone antibiotics, the risk of seizures may increase.

In patients receiving concomitantly NSAIDs and myelotoxic drugs, hematotoxicity increases.

With the simultaneous use of ibuprofen and cefamandol, cefoperazone, cefotetan, valproic acid, plikamycin, the incidence of hypoprothrombinemia increases.

With the simultaneous use of ibuprofen and drugs that block tubular secretion, there is a decrease in excretion and an increase in the plasma concentration of ibuprofen.

With the simultaneous use of ibuprofen and inducers of microsomal oxidation (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants), there is an increase in the production of hydroxylated active metabolites, an increase in the risk of severe intoxication.

Elderly age, heart failure, arterial hypertension, ischemic heart disease, cerebrovascular diseases, dyslipidemia, diabetes mellitus, peripheral arterial disease, smoking, frequent alcohol consumption, liver cirrhosis with portal hypertension, hepatic and / or renal failure, nephrotic syndrome, hyperbilirubinemia, peptic ulcer disease of the stomach and duodenum (in history), gastritis, enteritis, colitis, blood diseases of unknown etiology (leukopenia and anemia), pregnancy (I-II) trimester, lactation period, children's age from 6 to 12 years .. Children from 6 to 12 years: 1 tablet no more than 4 times a day, the drug can be used only if the child's body weight is more than 20 kg. The interval between taking the tablets is at least 6 hours (daily dose is not more than 30 mg / kg).